Conference Schedule
Day1: April 16, 2018
Keynote Forum
Valeriy Perminov
BioTeckFarm Ltd., Moscow, Russian
Title: Agent-based models for influenza epidemic dynamics and its decision-making capability
09:35-10:15
Biography
Dr. Valeriy D. Perminov was a senior researcher of Central Aerohydrodynamic Institute in Moscow for a long time. His research interests include rarefied gas dynamics, ill-posed problems, agent-based models and its application to infectious diseases spreading.
Abstract
Agents-based models (ABMs) become more and more popular in applied mathematics. During last 15 years large number of ABMs have been created and used in different scientific area (ecology, economy, epidemiology, human behavior to name a few), but in this talk I am going to tell only about ABMs for influenza epidemic/pandemic dynamics in cities.
Because of our only partial knowledge of agents’ rules for interaction with each other and with environment, such models contain unknown parameters. For our special ABMs these parameters are probabilities of getting infected in different age groups of citizens. These parameters usually are evaluate with help of several numbers extracted from available patterns and/or external considerations (for example, cumulated illness attack rates in age groups). Being integrals over lower level of agent population such numbers do not have unique and exact relationship with model’s parameters. So, the evaluation based on such numbers is carried out by a no unique selection of model parameters’ values that correspond to these numbers.
I will tell about a new approach to creation of ABMs together with mathematical substantiation of a correct method for evaluation of model’s parameters. Using this approach we get : a) a numerical assessment the model’s and patterns’ proximity and b) capability (under some conditions) to estimate a level of coming pandemic in the city under consideration and choose administrative and interventional measures before and during future outbreak and evaluate their efficiency and cost.
Zeliha Selamoglu
Nigde Omer Halisdemir University,Turkey
Title: A review on bioactivity of flavonoids in biotechnological applications
10:15-10:55
Biography
Zeliha Selamoglu is a Professor in Medical Biology Department of Nigde Ömer Halisdemir University, Turkey. She earned her PhD in Biology from Inonu University, Turkey. She has published over 90 peer-reviewed journal articles with over 760 citations and many technical reports. She is a Member of Society for Experimental Biology and Medicine: Associate Membership and European association for cancer research. She has served as Editorial Board member for many journals and her h-index:14 and 760 citations. Her research interest includes: Antioxidants, Biochemistry, Biotechnology, Cancer, Molecular Biology and Oxidative stress.
Abstract
Flavonoids are present in many phytomedicines or nutraceuticals to prevent oxidative damage related health problems. Flavonoids are found ubiquitously in plants as a member of phenolic compounds that share diverse chemical structure and function. Phenolic compounds have been acknowledged for their wide array of functions. Many of these compounds, such as plant phenolics, often exhibit antioxidant activities; therefore the addition of these compounds into food products may be helpful to health the of consumers and also to the stabilization of food products. Flavonoids are potent bioactive compounds that have anticarcinogenic effects since they can interfere with the initiation, development and progression of cancer by the modulation of cellular proliferation, apoptosis and metastasis. Due to the presence of some of these effective compounds such as flavonoids, phenolic acids and their esters in natural products such as plants and their extracts, if the positive physiological properties and the non-toxicity of the these products are proven it could be used as a mild antioxidant and preservative. The ethnopharmacological approach, combined with biochemical and biological modalities, may provide useful biotechnological leads. Due to their biotechnological and pharmacological activities, they have been used in folk medicine. Newly, investigations have been concerned over the different nutritional products due to their antioxidant potential to prevent or treat the diseases of human and animal.
Tracks
- Medical Biotechnology | Bioproducts and BioEnergy | Bioremediation and Biodegradation, Advancements in Biotechnology | Bioproducts and BioEnergy | Nanobiotechnology | Clinical Biochemistry Novel stem cell technologies | Cancer Stem Cells | Stem Cell Product Development & Comercialization | Veterinary Stem Cell | Tissue Regeneration & Therapeutics | Stem Cell Banking
- Young Researchers Forum
Location: Amsterdam, Netherlands
Zeliha Selamoglu
Nigde Omer Halisdemir University,Turkey
Chair
Utku AVCI
Recep Tayyip Erdogan University, Turkey
Co Chair
Mojgan Ahmadzadeh Raji
University of Tehran, Iran
Title: A Novel Aptamer- Conjugated Gold Nanoparticle for reliable cancer cell
15:15-15:40
Biography
Abstract
Robert Bowen
West Virginia University, USA
Title: Stromal Vascular Fraction from Lipoaspirate Infranatant
11:15-11:40
Biography
Abstract
Malyshev Igor
Moscow State University of Medicine and Dentistry named A.I. Evdokimov, Russia
Title: Biotechnology of tumor growth restriction: M3 macrophage “switch†phenotype and antigen-reprogrammed lymphocytes
11:40-12:05
Biography
Abstract
Bruno Zelic
University of Zagreb, Croatia
Title: Production of Biofuels by Micro-, Lab-, Pilot- and Industrial Scale Based Biocatalytic Processes
Biography
Bruno Zelić received his PhD in chemical engineering in 2003 at University of Zagreb. From 2012 he is full professor at the Faculty of Chemical Engineering and Technology, University of Zagreb. His research interests are in the field of implementation of microreactor technology into biotechnology and biofuels production. More than 80 scientific and professional publications, 2 patents, and more than 60 oral and poster presentations on the international conferences present his scientific work. Bruno Zelić was dean of the Faculty of Chemical Engineering and Technology, University of Zagreb from 2013 to 2017. He is Editor-in-Chief of Chemical and Biochemical Engineering Quarterly journal.
Abstract
Oliver Spadiut
Technische Universitat Wien, Austria
Title: Inclusion bodies – more than just waste!
12:30-12:55
Biography
Abstract
Haamid Bashir
Govt Medical College, India
Title: A study on Subclinical hypothyroidism and association with Vitamin D in ethnic population of Kashmir India
12:55-13:20
Biography
Abstract
Tamar Varazi
Agricultural University, Georgia
Title: About New Approaches for Enhancing Phytoremediation Effectiveness
14:00-14:25
Biography
Abstract
Zeliha Selamoglu
Nigde Ömer Halisdemir University, Turkey
Title: The effects of acrylamide and Vitamin E administration during pregnancy on adult rat ovary tissues
14:25-14:50
Biography
Abstract
Mija Sezun
Pulp and Paper Institute, Slovenia
Title: Paper mill sludge as a good substrate for enzyme production by oyster mushroom (Pleurotus ostreatus)
14:50-15:15
Biography
Abstract
Location: Amsterdam, Netherlands
Elodie Czuba
University of Strasbourg, France
Title: The charge effect of insulin PLGA nanoparticles on cell uptake in vitro and bioavailability in vivo
16:20-16:45
Biography
Abstract
Magdalena Arevalo Turrubiarte
University of Turin, Italy
Title: Analysis of different MSC tissue sources in horses
16:45-17:10
Biography
Abstract
Piyathip Setthawong
Chulalongkorn University, Thailand
Title: Induced pluripotent stem cells derived from porcine Sertoli cells
17:10-17:30
Biography
P Setthawong has completed her Bachelor's Degree in Faculty of Veterinary Science (First-Class Honors) from Chulalongkorn University, Thailand. She got a Scholarship in Thailand Research Fund through the Royal Golden Jubilee PhD Program (Grant No. PHD/0143/2556). She is currently pursuing a Doctor of Philosophy Degree in the field of Obstetrics, Gynaecology and Reproduction at Chulalongkorn University, Thailand. She is interested in veterinary stem cells especially in pig as an animal model for human. She aims to study about generation of embryonic stem cells and induced pluripotent stem cells. She has succeeded in establishing and characterizing induced pluripotent stem cells derived from Sertoli and fibroblast cells.
Abstract
Induced pluripotent stem cells (iPSCs) are generated by reprogramming of fully differentiated adult cells using four transcription factors, including OCT4, SOX2, KLF-4 and c-MYC (OSKM). Porcine is a meaningful model for regenerative medicine because its anatomy and physiology are similar to human. However, reprogramming efficiency of porcine fibroblasts into iPSCs is currently poor. This study used Sertoli cells as a novel cell origin for somatic cells reprogramming. Neonatal testes were collected from 1-week old piglets. The testes were digested by two-step enzymatic method in order to isolate the Sertoli cells. The Sertoli cells were transfected with retroviral vectors expressing OSKM. We observed the primary colonies and counted on day 7 after transfection. The characteristics of Sertoli iPSCs-like colonies were analyzed by morphology, alkaline phosphatase staining, RT-PCR, G-banding, in vitro and in vivo differentiation. Sertoli cells obtained from neonatal porcine showed typically polygonal shaped. A total of 240 colonies (0.33%) originated from seeding 72,500 cells were observed on day 7. The Sertoli iPSCs-like colonies exhibited a high nuclear per cytoplasm ratio with prominent nucleoli. We picked up 30 Sertoli iPSCs-like colonies and 8 cell lines (26.6%) demonstrated undifferentiated stage of iPSCs. The Sertoli iPSCs-like colonies were positive to alkaline phosphatase staining and expressed endogenous pluripotent. G-banding analysis demonstrated normal karyotype. Under differentiation conditions, iPS-like cell lines could form three-dimension aggregated masses, which represented three germ layers of embryonic cells. For in vivo differentiation, tumour mass were collected and presented all of ectoderm, mesoderm, and endoderm. In conclusion, the Sertoli cells can be used as a novel somatic cell origin for iPSCs reprogramming.
Biography
Saadia Ijaz is a Young Researcher. She has just completed her PhD in April, 2017 from The University of the Punjab, Lahore Pakistan. Currently she is working as Assistant Professor in The Women University, Multan Pakistan. Her main research interest is in the role of Cyanobacteria in biotechnology including but not limited to nutraceutical, pharmaceutical, biofuel production, environmental biosensors, cosmetics, biomedical research applications and harmful aspects of cyanobacteria. She has published 2 research papers in impact factor journals and also won Rs. 0.5 million Start-up research grant from Higher Education Comission of Pakistan for her work with anticancer carotenoids from Cyanobacteria.
Abstract
The 70% methanolic extract of Cyanobacterial strain; Oscillatoria sp. SI-SA containing phenolic compounds; Tannic acid, Orcinol, Pholoroglucinol, Salicylic acid, Acetyl Salicylic acid and Protocatechuic acid, was evaluated for its non-cytotoxic, non-genotoxic and non-mutagenic activities along with its anticancer potential against two (MCF-7 and MDA-MB-231) breast cancer cell-lines in order to study their chemotherapeutic effects without causing damage to normal cells. The strain was isolated from Kallar Kahar Salt Lake, Pakistan. It was identified by polyphasic approach including both morphological and molecular methodologies. The extract showed very low cytotoxicity against normal lymphocytes only at highest concentration of 1000 µg/ml with high IC50 value of 1088 µg/ml. Comet assay also showed low genotoxicity only at highest non-cytotoxic concentration of 1000 µg/ml with 15.37% DNA damage. Ames fluctuation Salmonella typhimurium test against four mutant strains TA100, TA98, TA97a and TA102 also showed significant non-mutagenic effects of the extract with and without metabolic activation. Finally, the extract was evaluated for its anticancer potential which showed significant anticancer activities in dose-dependent manner against MCF-7 and MDA-MB-231 cell-lines giving low IC50 values of 61.75 and 82.75 µg/ml respectively. It was further observed that after three days of treatment with the extract, 19.29 and 26.81 % cell viability remained of MCF-7 and MDA-MB-231 cell-lines respectively at highest concentration of 250 µg/ml. The phenolic extract of Oscillatoria sp. SI-SA indeed showed promising anticancer activities without causing severe damage to normal cells and thus could be used as an alternative bioresource for anticancer therapeutics against breast cancers.
Day2: April 17, 2018
Keynote Forum
Deven Patel
Global Institute of Sten Cell Therapy and Research,USA
Title: The Stem Cell Therapy and its emerging markets
09:30:10:10
Biography
Mr. Deven Patel, the CEO, President and Cofounder of Global Institute of Stem Cell Therapy and Research (GIOSTAR) with headquarter in San Diego, California, U.S.A. GIOSTAR was formed with the vision to provide affordable stem cell based therapies to the masses around the world suffering from degenerative or genetic diseases and unable to afford today’s high cost of the treatment. He was honored with USA Congressional Recognition for his efforts in spreading the advancement of stem cell science around the world. He was also bestowed upon Asian Heritage Award for his business leadership in the field of stem cell science. GIOSTAR under the leadership of Mr. Patel is in charge of developing stem cell transplant program for four different State Governments in India with total population of approx. 155 million. GIOSTAR, in collaborations with Government of Gujarat, India, world's largest state of the art Stem Cell Treatment Hospital in India.
Abstract
The field of stem cell research has come a long way from the early days of bone marrow transplant and progressed into sophisticated domain of autologous, allogeneic and embryonic stem cell and has largely escaped the risks faced during the emergence of genetic engineering. In fact, it has reached critical mass with several companies carrying out cutting edge research and several government organizations are recognizing the significant impact it would have in the well being of humanity with the promise of significant reduction of healthcare costs. We are already seeing evidence of positive impact on patients suffering from Autism, Alzheimer’s, MS, and Cerebral Palsy. And its only going to get better once the brilliant research meets the motivation of government and capital markets to bring this epoch-making technology to market and help cure degenerative diseases for the first time in human history.
Tracks
- Work Shop
- Medical Biotechnology | Reproductive Biotechnology | Plant and Agriculture Biotechnology | Pharmaceutical Biotechnology | Clinical Research | Advancements In Biotechnology |Â Stem Cell Product Development & Commercialization | Stem Cell Transplantation & Techniques | Ethical Issues In Stem Cell Research | Tissue Regeneration & Therapeutics | Stem Cell apoptosis and signal transduction
Location:
Ghislaine Robert
University of Montreal, Canada
Title: The Science behind PRP and Stem Cell injections used in regenerative medicine
10:10-11:10
Biography
Dr Ghislaine Robert renowned International sports physician will present the science behind PRP and Stem cell injections used in regenerative medicine. Combining her knowledge and lengthy experience using PRP (Platelet Rich Plasma) and more recently Stem Cells, Dr Robert will detail how these methods can be used to treat the whole patient naturally. She will go over indications, contraindications and results with different procedures (both MSK and non MSK).
Abstract
This WORKSHOP will review the science behind PRP and stem cell injections and their clinical use in Sports Medicine and Regenerative Medicine. We will explain the harvesting and preparation of those injections, talk about their clinical indications for injuries, osteoarthritis, cosmetic use and male/female health function. Clinical results will be discussed and the presentation will end with open discussion with the audience. Dr Robert currently uses PRP and stem cell injections to treat medical issues such as cartilage damage, tendon and ligament tears and cosmetic issues including; stretch marks, hair loss, acne scarring, facial wrinkles and skin texture. In addition to the above Dr Robert also provides treatment for ED and female dysfunction using the same method. Dr Robert will discuss relevant cases under her treatment and share experiences as a clinician involved in Elite athlete care for the past few decades.
Location: Amsterdam, Netherlands
Chandan R Bora
Fidelity Healthcare ltd, Trinidad
Title: Efficacious dendritic cell based immunotherapy for advanced multiple malignancies
11:30-11:55
Biography
Chandan R Bora completed his Master’s Degree from SGB Amravati University (India) and Doctorate Degree from Rani Durgavati Vishwavidyalaya (India). He currently holds the position of a Director at NOVO Cellular Medicine Institute, Fidelity Healthcare Ltd, Trinidad & Tobago. His research areas are Immunology, Microbiology and Molecular Biology. He has presented research papers in many national and international conferences. He has also published national and international research papers, reviews and book chapters. He is the Editorial Board Member of the journal BOAJ Cancer Research and Therapy and active Advisory Board Member of Bio
Abstract
11:55-12:20
Biography
Mark Engelman is a pharmacologist (King’s Lond.), trained as a barrister. Having practiced with in 2 firms of IP specialist solicitors, 2 major multinationals, he is head of IP at Hardwicke, a set of barristers. He has been non-executive directors of companies which include Alexander McQueen and the patent owner of the Mechano Growth Factor suit of patents. He acts for numerous multinationals. He is a Research Associate as St Edmunds College Cambridge in IP and Bencher of the Hon Soc. of Gray’s Inn, London. He is he legal correspondent for The Pharma Letter.
Abstract
A discussion concerning the legal recognition of copyright rather than patent in DNA nucleotide sequences as they relate to Mechano growth factor. A discussion of Emergent Genetics India Pvt. Ltd V Shailendra Shivam, Ravindra. With this case we finally have a ruling on the interesting debate on copyrightability of DNA sequences which had been brewing for some time.
Omid Koohi-Hosseinabadi
Shiraz University of Medical Science, Iran
Title: Healing effect of Pistacia atlantica hydroalcoholic extract with bone marrow mesenchymal stem cells on knee Osteoarthritis
12:20-12:45
Biography
Abstract
Olexandr Korchynskyi
Rzeszow University, Poland
Title: Viral Gene Delivery Tools In Optimization Of Human Mesenchymal Stem Cells’ Osteoblast Differentiation
12:45-13:10
Biography
O Korchynskyi has completed his PhD from Institute of Animal Biology, Lviv, Ukraine and Postdoctoral studies at the Netherlands Cancer Institute, Amsterdam, Netherlands and University of North Carolina, Chapel Hill, NC, USA. Currently he is the Associate Professor at the Rzeszow University, Poland and the Senior Scientist at the Institute of Cell Biology, Lviv, Ukraine. He has published more than 30 papers in reputed journals including Nature and Science.
Abstract
Zeliha Selamoglu
Nigde Omer Halisdemir University, Turkey
Title: Varicocele and its effects on the male reproductive system
13:10-13:35
Biography
Zeliha Selamoglu is a Professor in Medical Biology department of Nigde Ömer Halisdemir University, Turkey. She earned her PhD in Biology from Inonu University, She has published over 90 peerreviewed journal articles with over 800 citations and many technical reports. She is a member of Society for Experimental Biology and Medicine: Associate Membership and European association for cancer research. She has served as Editorial Board member for many Journals.
Abstract
Varicocele is a disorder characterized by abnormal dilation of testicular venules in the pampiniform plexus. This disorder is one of the most important causes of infertility. This illness affects 15-22% of the adult male population and it is seen in 30-40% of the infertile patients. In cases of secondary infertility diagnosis, the incidence of varicoceles increases to 69-81%, while 80% of varicocele-diagnosed cases have no infertility. In many studies, varicoceles have been shown to cause progressive histopathologic alterationes in animal and human testes. In a project of the World Health Organization that shows Varicocel's effects on fertility; it is reported that this disease is associated with semen anomalies (deterioration in number and motility), testicular volume and decreased Leydig cell function. Although the varicocele pathophysiology has not yet been fully elucidated, it is asserted that it may caused from factors including oxidative stress, apoptosis, hormonal dysfunction, acrosome reaction defect, heavy metals, autoimmunity, hyperthermia, changes in testicular blood flow and venous pressure. The role of reactive oxygen species (ROS) in the development of varicocele and varicosele associated testicular damage has been investigated in many studies. Although an increase in ROS concentration was found in 80% of varicocele infertile patients, this increase was found in 77% of varicocele fertile man and in 20% of non-varicocele fertile individuals. In addition, the total antioxidant capacity of normal individuals was significantly higher than those of varicoceles. it was suggested that in patients with varicocele, apoptosis plays an important role in the development of oligospermia. In the one study suggests that during normal spermatogenesis 75% of all preleptotene spermatocytes can be removed by apoptosis. Although the most radical treatment of varicocele is surgical operations, recently has been shown some pharmacological agents (especially antioxidants) that can use as alternative treatment in cases of infertility due to varicoceles.